Mechanisms underlying reliable motor output
I am currently investigating the neural basis of skilled movement. Most brain functions rely on interactions between multiple, functionally distinct regions, and the execution of reliable, goal-directed actions requires the coordinated activity of several neural populations. Despite their importance, the mechanisms that enable precise and consistent communication between neuronal groups separated by millimeters remain poorly understood.
In collabration with Hammad Khan
Multimodal Neural Recording Platform
We present a chronic multimodal platform capable of long-term, simultaneous electrophysiological recording and two-photon calcium imaging. We fabricated 32-channel transparent and flexible surface μECoG arrays, enabling optical access for two-photon imaging through the grid. Using this platform, we investigated the evolution of surface potentials and neural ensemble dynamics throughout the course of motor learning.
In collabration with Alec Booth
Accepted for an Oral Presentation in The 23rd International Conference on Solid-State Sensors,Actuators and Microsystems
3D electrodes for mapping cortical dynamics
Conventional electrodes are limited to recording in only one or two dimensions. We are developing a three-dimensional electrode array capable of capturing electrical activity across an entire 3D volume of brain tissue.
ASIC for simultaneous electrophysiology and electrochemistry
Neurons communicate through multiple modalities, including electrical spiking activity and chemical signaling via neuromodulators such as dopamine. Dopamine plays a key role in learning and reward-based reinforcement, yet its precise effects on neural activity remain poorly understood. The application-specific integrated circuit (ASIC) developed in this project enables simultaneous electrophysiological and electrochemical recordings. This dual capability allows us to detect subtle fluctuations in dopamine levels and directly examine their influence on neural dynamics.
